Custom DNA Oligos


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PRODUCT DETAILS

MaxPrecision Lab’s DNA oligo synthesis platform equips state-of-the-art synthesizers and leading professional teams with vast experience in oligo synthesis. This allows us to provide high-quality custom DNA oligo products to scientific researchers and industrial customers around the world. By leveraging our advanced and innovative manufacturing process, MaxPrecision Lab offers a wide range of custom DNA oligo synthesis options. These custom DNA oligo synthesis options include standard oligos, micro-oligos, large-scale oligos, degenerate primers, long oligos synthesis, etc.
MaxPrecision Lab is always competent to provide tailor-made approaches to accomplish every oligo synthesis request.

Competitive Advantages

  • High-Quality:Extremely low mutation and low error rates, in accordance with the stringent quality control standards for oligo synthesis.
  • Good Stability:Unrivaled control of oligo specifications ensures batch-to-batch consistency and traceability.
  • Highly-Customizable:Flexible synthesis scales are available; four alternative purification options include DSL, PAGE Plus, PAGE, and HPLC.
  • Technical Support:Professional teams experienced in oligo synthesis and various modifications offer support throughout the entire production progress.
  • Cost-Effective:Competitive prices and affordable services.

MaxPrecision Lab provides a fast and convenient standard DNA oligo synthesis. Large scale and bulk custom DNA oligos can be ordered with the same high purity, competitive prices, and fast turnaround.

Standard Oligo Synthesis

Standard Oligo Synthesis (Price per Base)
Synthesis Scale 10nm 25nm 50 nmol 100 nmol 200 nmol 1 μmol
11-59nt Available Available Available Available Available Available
60-90nt Available Available Available Available Available Available

* Longer oligos, 96/384 plate batch oligos or other large scale synthesis are available, please contact us for a quote.

* Please refer to the purification table for the final output corresponding to different synthesis scale.

Purification
11-59nt Purification Method Synthesis Scale 10nm 25nm 50 nmol 100 nmol 200 nmol 1 μmol
DSL Final Yield 1 OD 2 OD 5 OD 10 OD 15 OD 50 OD
  Available Available Available Available Available Available
PAGE Plus Final Yield 2 OD 5 OD 10 OD 30 OD
Price Available Available Available Available
PAGE Final Yield 2 OD 5 OD 10 OD
Price Available Available Available
HPLC Final Yield 2 OD 5 OD 10 OD
Price Available Available Available
60-90nt DSL Final Yield 1 OD 2 OD 5 OD 10 OD 15 OD 50 OD
Price Available Available Available Available Available Available
PAGE Plus Final Yield 2 OD 5 OD 10 OD 30 OD
Price Available Available Available Available
PAGE Final Yield 2 OD 5 OD 10 OD
Price Available Available Available
HPLC Final Yield 2 OD 5 OD 10 OD
Price Available Available Available

* The total price of oligo=price/base*nt + purification price.

* If you need other synthesis scale and lengths, please contact us for a quote.

* For modified oligos please click Oligo Modification & Labeling

Micro Scale Oligos

With a micro-synthesis technology platform, MaxPrecision Lab can provide customers with economized micro-scale oligo synthesis services to help customers avoid the waste of experimental raw materials and reduce unnecessary costs.

Competitive Advantages

  • Cost-Effective: As low as half of the price of conventional synthesis, greatly reducing the cost of scientific research.
  • Quality Assurance: Strict quantitative analysis ensures that each oligo is mixed and delivered according to the requirements.
  • Highly-Customizable: Customized synthesis is available, including phosphoric acid, amino, biotin, and other modifications.

Service Specifications

Service Types Service Specifications
Length 15-90nt, no fewer than 96 oligos
Final Yield 0.1-1 nmol
Purification Desalt or PAGE Plus
Turnaround Time/Price Inquire
Deliverables Plate delivery or pool delivery

Standard deliverables

  • Lyophilized dry DNA oligo powder, 1 tube (Transparent or dark) or 96-well and 384-well plates.
  • Certificate of Analysis (COA): including sequencing information, OD, Tm, etc.

Large-Scale Oligos

MaxPrecision Lab has large-scale synthesis and purification facilities that utilize mature and stable industrial synthesis technologies to provide high-quality, large-scale customized oligo synthesis services for global industrial production. We can provide mass production of oligos with high purity from milligram to gram quantities. These oligos are mainly used in kit development, drug discovery (ASOs drugs), aptamers, DEL (DNA encoded compound library), research fields, etc.

Competitive Advantages

  • High-Quality:Strict production process and QC quality inspection.
  • Output Capacity:Diversified purification methods and strict detection standards ensure high quality output of large-scale oligos.
  • Highly Customized:Flexible synthesis scales and various modifications.

Service Specifications

Large-Scale Oligo Synthesis
Final Yield 10–25 nt 26–40 nt 41–55 nt >55 nt
25 mg Available Available Available Inquire
50 mg Available Available Available
100 mg Available Available Available
200 mg Available Available Available
250 mg Available Available Available
500 mg Available Available Available
1 g Available Available Available

*If you need to know the turnaround time and the price of modified DNA oligos, please contact us for a quote.

Purification QC Analysis Deliverables Modifications and Probes
Backbone Modifications Linker Modifications qPCR Probes
HPLC/ PAGE
  • HPLC/LC-MS
  • Endotoxin Control/Bioburden (optional)
  • Lyophilized products
  • COA file
  • Phosphorothioate
  • 2’F-RNA
  • 2′-O-Methyl
  • MOE-RNA
  • LNA
  • Amino
  • Biotin
  • Thiol
  • Digoxigenin
  • Acrydite
  • DBCO
  • Azide
  • MGB Probe
  • BHQ Probe
  • Dabcyl Probe
  • TAMRA Probe

Standard deliverables

  • Lyophilized dry DNA oligo powder, 1 tube (Transparent or dark) or 96-well and 384-well plates.
  • Certificate of Analysis (COA): including sequencing information, OD, Tm, etc.

Degenerate Primers

Genetic codes have the tendency to degenerate, which lead to the use of degenerate primers in PCR experiments to exhibit specific genes. MaxPrecision Lab provides both the design and synthesis of these degenerate primers, as well as custom degenerate oligo pool synthesis upon request.

  • Standard Service: No design fee, suitable for more than 95% PCR projects.
  • Superior Service: Utilized for certain projects sensitive to codon bias. MaxPrecision Lab can significantly reduce the deviation inherent in the synthesis procedures and realize the accurate proportional control.
Symbol Base Type Standard Ratio Price
Standard Level Superior Level
R A,G 50% : 50% Free Inquire
Y C,T 50% : 50%
M A,C 50% : 50%
K G,T 50% : 50%
S C,G 50% : 50%
W A,T 50% : 50%
H A,C,T 33% : 33% : 33%
B C,G,T 33% : 33% : 33%
V A,C,G 33% : 33% : 33%
D A,G,T 33% : 33% : 33%
N A,C,G,T 25% : 25% : 25% : 25%

* Non-standard base proportion should be declared clearly, for example, N(20%A:30%C:40%G:10%T).

Long Oligos

Based on the solid-phase oligo chemical synthesis technology, as the length of the synthetic sequence increasing, the undesired bands of N-1 type impurities are more unavoidable in the electrophoresis. However, some experiments still need to use long chain genes or ultra-long oligos (130-150 mer). In doing so, the synthesis efficiency and purification are pretty crucial. MaxPrecision Lab’ Oligo Synthesis Platform utilizes an optimized ultra-long chain design and synthesis program to meticulously monitor and control the synthesis process. This process allows us to generate long high-quality oligos (90-129 mer) and even ultra-long oligos (130-150 mer) according to individual requests.

Length Quantity Purification Turnaround Time Price
90-109 mer 1 OD PAGE / Dual-PAGE 5-6 business days Inquire
110-129 mer 1 OD 5-7 business days
130-150 mer 0.5 OD 5-8 business days

Standard deliverables

  • Lyophilized dry DNA oligo powder, 1 tube (Transparent or dark) or 96-well and 384-well plates.
  • Certificate of Analysis (COA): including sequence information, OD, Tm, etc.